| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Design of antiseptic formulations containing extract of Plinia cauliflora
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| Autores: |
Oliveira,Lara Alexandre de
Souza-Moreira,Tatiana Maria de
Cefali,Letícia Caramori
Chiari,Bruna Galdorfini
Corrêa,Marcos Antonio
Isaac,Vera Lucia Borges
Salgado,Hérida Regina Nunes
Pietro,Rosemeire Cristina Linhari Rodrigues
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| Data: |
2011-09-01
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| Ano: |
2011
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| Palavras-chave: |
Antiseptic formulations/design
Plinia cauliflora/antimicrobial activity
Plinia cauliflora/antiseptic activity
Mouthwash
Plant extract
Topical cream
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| Resumo: |
The leaves of the Brazilian species Plinia cauliflora were used to obtain active hydroalcoholic extract and fractions enabling the development of efficient antiseptic pharmaceutical formulations. A chemical composition of 70% ethanol extract, aqueous and ethyl acetate fractions was analyzed by thin-layer chromatography and for phenol content. Antimicrobial activity was tested against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Lactobacillus acidophilus and Candida albicans by the agar diffusion method and the minimum inhibitory concentration was assayed by broth microdilution. Extract microbiological quality was tested to avoid contamination in the formulations. A mouthwash and a topical cream containing the extract were developed and antiseptic activity was assessed by agar diffusion. Sensory and physicochemical stability of the formulations were assayed. Chromatography indicated the presence of terpenes, flavonoids and tannins in the extract and fractions and total phenol content were found to be high. The plant samples were active against all the microorganisms tested, except for Lactobacillus acidophilus. Both topical formulations showed antiseptic activity and stability. Thus, these may be used as antimicrobials in skin infections, but would be more useful in the treatment of candidiasis.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300010
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502011000300010
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.47 n.3 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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